منابع مشابه
Association between matrix metalloproteinase‐9 and worsening heart failure events in patients with chronic heart failure
AIMS Matrix metalloproteinase (MMP) is up-regulated during heart failure (HF) and influences ventricular remodeling. We hypothesized that disparity between MMP-9 and tissue inhibitors of MMP-1 (TIMP-1) results in clinical manifestations and is related to prognostic risk in patients with chronic HF. METHODS AND RESULTS Plasma levels of MMP-9, TIMP-1, and brain natriuretic peptide (BNP) were me...
متن کاملTubular damage and worsening renal function in chronic heart failure.
OBJECTIVES This study sought to investigate the relationship between tubular damage and worsening renal function (WRF) in chronic heart failure (HF) BACKGROUND: WRF is associated with poor outcome in chronic HF. It is unclear whether urinary tubular markers may identify patients at risk for WRF. METHODS In 2,011 patients with chronic HF, we evaluated the ability of urinary tubular markers (N-...
متن کاملA patient with heart failure and worsening kidney function.
There is high prevalence of CKD, defined by reduced GFR, in patients with heart failure. Reduced kidney function is associated with increased morbidity and mortality in this patient population. The cardiorenal syndrome (CRS) involves a bidirectional relationship between the heart and kidneys whereby dysfunction in either may exacerbate the function of the other, but this syndrome has been diffi...
متن کاملIn‐hospital worsening heart failure: a clinically relevant endpoint?
Outcome measures used for the clinical evaluation of patients with acute heart failure differ between studies and may neither adequately address the characteristic presenting symptoms and signs nor reflect the pathophysiological processes involved. In-hospital worsening of heart failure (WHF) is associated with poor outcomes and thus a potential endpoint conveying clinically meaningful prognost...
متن کاملThe Impact of Worsening Heart Failure in the United States.
In-hospital worsening heart failure represents a clinical scenario wherein a patient hospitalized for acute heart failure experiences a worsening of their condition, requiring escalation of therapy. Worsening heart failure is associated with worse in-hospital and postdischarge outcomes. Worsening heart failure is increasingly being used as an endpoint or combined endpoint in clinical trials, as...
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ژورنال
عنوان ژورنال: JACC: Heart Failure
سال: 2015
ISSN: 2213-1779
DOI: 10.1016/j.jchf.2015.02.003